Adipex History

Adipex history first began when medical researchers became interested in the effects of amphetamines when they were provided to soldiers during World War II to increase metal alertness and focus and decrease fatigue and appetite. Extrapolating from these physical effects caused in soldiers, testing of amphetamine class compounds such as Phentermine (Adipex) were continued after the war. In particular, this class of drugs was examined for their ability to induce a feeling of euphoria, diminish appetite and control weight.

In 1959 the FDA approved the use of Phentermine as an appetite reducing drug and this gave way to the development of Adipex. In the early 1970’s the use of phentermine hydrochloride for appetite suppression was also approved, which spawned the manufacturing of a number of different brand name and generic forms of this drug, many of which are still around today.

Despite having such a long history compared to other diet pills, there are relatively few human clinical studies that have been conducted with Adipex or phentermine hydrochloride that explore long-term side effects and weight loss benefits. The majority of clinical studies that have been done have focused on the combination of phentermine (Adipex) with fenfluramine and dexfenfluramine.

Fenfluramine was first introduced to markets in 1973 as an effective appetite suppressant. It was not long from this point that it was discovered that the combination of Fenfluramine with Phentermine increased the effectiveness of both these drugs. This famous combination, known as Fen-Phen, was considered the most powerful anti-obesity medication available.

In 1990, after years of Fen-Phen being prescribed and used to treat obesity, a study was released that suggested this combination of drugs was causing severe and life-threatening side effects including pulmonary hypertension (PPH) and heart valve disease. Despite this research it took seven more years for Fen-Phen to be withdrawn from markets world wide.

Fenfluramine was not the only drug combined with Phentermine for enhanced weight loss effects. For example, Prozac when combined with Phentermine (known as Phen-Pro) helps to extend the effectiveness of phentermine so that patients can take it for longer than 12 weeks. However, like Fen-Phen, these off-label combinations of phentermine with other drugs have not been clinically studied.